San Diego Padres vs Milwaukee Brewers — Mar 21, 2026 | AI Prediction & Stats

Milwaukee hands the ball to Freddy Peralta, while San Diego counters with veteran Yu Darvish. Peralta’s strike-out stuff keeps run creation modest early, but his occasional command lapses surface in the 2nd inning when Tatis Jr. rips a first-pitch fastball into the left-field seats after a Ha-Seong Kim walk, giving the Padres a 2-1 lead. Darvish mixes cutters and splitters, neutralising Milwaukee’s left-hand bats and allowing just two hard-hit balls through the first four frames; one of them is a solo blast by William Contreras in the 2nd that puts the Brewers briefly on top. The middle innings tip in San Diego’s favour. In the 4th, Manny Machado turns a slider left over the plate into an RBI double. Peralta exits after five; Bryce Wilson surrenders a run in the 6th on a Xander Bogaerts sac-fly. Milwaukee claws back within two on a Christian Yelich RBI single in the 7th against Steven Wilson, but the Padres’ bullpen tightens. Nick Martinez and Robert Suarez bridge the gap to Josh Hader, who doesn’t face his former club in a save situation thanks to San Diego’s 8th-inning surge: Jake Cronenworth hooks a two-run double down the line off Hoby Milner, stretching the margin to 6-3. Hader closes a three-run cushion with little drama. San Diego’s recent offensive uptick (175 runs on the year) and superior late-inning relief show again, while Milwaukee’s lineup continues its boom-or-bust pattern. Padres take it 6-3, winning five of the last six head-to-head meetings and solidifying their push toward the top half of the standings.